Author
Peking UniversityORCID 0000-0002-4674-4801Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Ruyi Cai, Yueqi Yang, Shangxuan Cai, Ana Isabel Silva de Sousa, Kathryn L. Todd, Lei Wang, WeiJian Teo, Ao Dong, Shuaiyu Chen, Hui Dong, Huan Wang, Zhaofa Wu, Yanling Qiao, Peng Xu, Chen Song, , Yulong Li
The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.
bioRxiv · Aug 12, 2026 · PreprintNeuroscience
Shu Xie, Xiaolei Miao, Guochuan Li, Yu Rong Zheng, Mengyao Li, En Ji, Jinxu Wang, Shaochuang Li, Ruyi Cai, Lan Geng, Jiesi Feng, Changwei Wei, Yulong Li
The paper develops red-shifted GRAB acetylcholine sensors for multiplex imaging of ACh and other neuromodulators in vivo with high spatiotemporal resolution.
Nature Neuroscience · Jun 16, 2026Peer-reviewedNeuroscience
Xue Liu, Hongren Huang, Xiaolong Feng, Xulin Li, Jialin Ye, Huan Min Yang, Jingjing Liu, Zicong Liang, Zhihan Guo, Ruyi Cai, Shangxuan Cai, Yulong Li, Zhaofa Wu, Liping Wang
The paper identifies a female-specific subcortical circuit involving CB1R that maintains defensive homeostasis during risk assessment by modulating GABA release in the lateral habenula.
bioRxiv · Sep 23, 2025 · PreprintNeuroscience
Yu Rong Zheng, Ruyi Cai, Kui Wang, Junwei Zhang, Yizhou Zhuo, Hui Dong, Yuqi Zhang, Yifan Wang, Fei Deng, En Ji, Yiwen Cui, Shilin Fang, Xinxin Zhang, Haiyun Huang, Kecheng Zhang, , Yulong Li
The paper introduces a far-red dopamine sensor, HaloDA1.0, enabling multiplex imaging of neurochemical networks in vivo with high sensitivity and versatility.
Science · Jun 5, 2025Peer-reviewedNeuroscience
Michaela Dvořáková, Taryn Bosquez-Berger, Jenna Billingsley, Natalia Murataeva, Taylor J. Woodward, Emma Leishman, Anaëlle Zimmowitch, Anne Gibson, Jim Wager‐Miller, Ruyi Cai, Shangxuan Cai, Tim Ware, Ku‐Lung Hsu, Yulong Li, Heather B. Bradshaw, , Alex J. Straiker
The paper shows acetaminophen inhibits DAGLα, reducing 2-arachidonoyl glycerol production and suggesting a novel antinociceptive mechanism involving DAGLα/CB1 circuits.
Cell Reports Medicine · May 16, 2025Peer-reviewedNeuroscience
Mingyue Lv, Ruyi Cai, Renzimo Zhang, Xiju Xia, Xuelin Li, Yipan Wang, Huan Wang, Jianzhi Zeng, Yifei Xue, Lanqun Mao, Yulong Li
The paper develops a GRAB sensor to monitor octopamine release in Drosophila and reveals its role in aversive learning through a monoamine relay circuit.
National Science Review · Mar 25, 2024Peer-reviewedNeuroscience
Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T. Williams, Malcolm G. Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J. Weber, Lei Wang, Bozhi Li, Yu Wei, , Yulong Li
The paper develops improved GRABDA sensors to monitor dopaminergic activity in vivo, showing high sensitivity and spatially resolved DA release in mice during behaviors.
Nature Methods · Nov 30, 2023Peer-reviewedNeuroscience
Ao Dong, Kaikai He, Barna Dudok, Jordan S. Farrell, Wuqiang Guan, Daniel J. Liput, Henry L. Puhl, Ruyi Cai, Huan Wang, Jiali Duan, Eddy Albarran, Jun Ding, David M. Lovinger, Bo Li, Iván Soltész, Yulong Li
The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.
Nature Biotechnology · Nov 11, 2021Peer-reviewedNeuroscience