A sterol-binding pocket in iRhom1 underlies paralog-specific regulation of the sheddase ADAM17
Fangfang Lu, Hongtu Zhao, Yaxin Dai, Chia‐Hsueh Lee, Matthew Freeman
This study identifies a sterol-binding pocket in iRhom1 that regulates ADAM17 stability and shedding activity, distinct from the paralog iRhom2.
bioRxiv · May 1, 2026 · PreprintCell Biology