Fangfang Lu

This study identifies TMEM115 as a two-factor component with Rab6A that recruits the golgin TMF1 to the Golgi apparatus, with implications for protein trafficking and disease.

This study identifies a sterol-binding pocket in iRhom1 that regulates ADAM17 stability and shedding activity, distinct from the paralog iRhom2.

The paper presents a CRISPR-Cas9-mediated F0 screen in zebrafish to identify genes regulating RPE regeneration, finding eight positive and seven negative regulators, including cldn7b with novel roles in macrophage infiltration and debris clearance.

This study shows that mTOR activity is necessary and sufficient for RPE regeneration in zebrafish, with immune cell interactions playing a key role in this process.