Matthew Freeman

This study identifies TMEM115 as a two-factor component with Rab6A that recruits the golgin TMF1 to the Golgi apparatus, with implications for protein trafficking and disease.

This study identifies a sterol-binding pocket in iRhom1 that regulates ADAM17 stability and shedding activity, distinct from the paralog iRhom2.

The paper develops an 'Unknome database' to prioritize understudied proteins and validates their functions using Drosophila RNAi and CRISPR/Cas9.

The paper shows that ADAM17-triggered TNF signaling in Drosophila retina protects against age-related lipid droplet-mediated degeneration by initially buffering ROS but later causing toxic lipid release.

This study identifies Rhbdf2 as a gene influencing bone microarchitecture through a genome-wide association study in Collaborative Cross mice.