The two-component nuclease-active KELShedu system confers broad antiphage activity via abortive infection
Hengwei Zhang, Jiajia You, Hanwen Zhou, Zan Zhang, Hongxuan Wu, Di Zhang, Xuewei Pan, Weiguo Zhang, Xian Zhang, Zhiming Rao
The paper characterizes the KELShedu system in E. coli, showing it confers antiphage activity through abortive infection by degrading DNA when NTP levels drop during phage invasion.
Science Advances · Oct 31, 2025Peer-reviewedMicrobiology