Xian Zhang

Mast cell-driven adipocyte lipolysis promotes post-expansive VAT atrophy and ectopic hepatic steatosis

This study identifies mast cells and their derived serotonin as drivers of adipocyte lipolysis, leading to visceral fat atrophy and hepatic steatosis in obesity.

The two-component nuclease-active KELShedu system confers broad antiphage activity via abortive infection

The paper characterizes the KELShedu system in E. coli, showing it confers antiphage activity through abortive infection by degrading DNA when NTP levels drop during phage invasion.

SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering

SAKPE predicts enzyme kinetic parameters with improved accuracy by incorporating weighted protein representations, outperforming existing methods in kcat, Km, and Ki predictions.

Morphological deconvolution of beta-lactam polyspecificity in E. coli

This paper develops an image-based assay with machine learning to profile beta-lactam antibiotic activity in E. coli by analyzing morphological changes linked to PBP specificity.