Piezo1 Triggers an Angiopoietin-2-Integrin Signaling Loop in Schlemm's Canal to Regulate Intraocular Pressure
Naoki Kiyota, Dilip K. Deb, Hongyuan Ren, Kerolous Salama, Yalu Zhou, Haiyan Gong, Benjamin R. Thomson, Susan E. Quaggin
The paper identifies a PIEZO1-ANGPT2-ITGA9 signaling pathway in Schlemm's canal endothelium that regulates intraocular pressure and glaucoma.
bioRxiv · Oct 24, 2025 · PreprintCell Biology