Author

Haiyan Gong

Boston UniversityORCID 0000-0002-7204-5019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Benjamin R. ThomsoniD· 3 shared Dilip K. DebiD· 2 shared Hoi‐Lam LiiD· 2 shared Hyunjoo Jean LeeiD· 2 shared Naoki KiyotaiD· 2 shared Susan E. QuagginiD· 2 shared Yalu Zhou· 2 shared Constance E. RunyaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

Benjamin R. ThomsonORCID

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3 papers

Recent·Most cited

VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and Humans

Naoki Kiyota, Yalu Zhou, Dilip K. Deb, Guohui Ren, Tuncer Onay, Ester Reina‐Torres, Hoi‐Lam Li, Constance E. Runyan, Robert S. Feder, Hyunjoo Jean Lee, Darryl R. Overby, Haiyan Gong, G. R. Scott Budinger, Benjamin R. Thomson, Susan E. Quaggin

This study identifies VEGFA-producing macrophages around Schlemm's canal as a compensatory mechanism maintaining aqueous humor outflow during aging and vascular stress, suggesting TIE2 activation as a therapeutic target.

bioRxiv · Sep 11, 2026 · PreprintPhysiology

PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension

Sofia Lara Ochoa, Hoi‐Lam Li, Hyeohn Kim, Zihang Yan, Natalia C Mendonca, Pan Liu, Hyunjoo Jean Lee, Michael P. Vincent, Sultan Almunif, Hao F. Zhang, Haiyan Gong, Evan Alexander Scott, Mark Johnson, Benjamin R. Thomson

This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.

JCI Insight · May 5, 2026Peer-reviewedPhysiology

Piezo1 Triggers an Angiopoietin-2-Integrin Signaling Loop in Schlemm's Canal to Regulate Intraocular Pressure

Naoki Kiyota, Dilip K. Deb, Hongyuan Ren, Kerolous Salama, Yalu Zhou, Haiyan Gong, Benjamin R. Thomson, Susan E. Quaggin

The paper identifies a PIEZO1-ANGPT2-ITGA9 signaling pathway in Schlemm's canal endothelium that regulates intraocular pressure and glaucoma.

bioRxiv · Oct 24, 2025 · PreprintCell Biology