Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer disease
Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, Horst Wallrabe, Evelyn Pardo, Taylor Kim, Shagufta Rehman Alam, Song Hu, Ammasi Periasamy, George S. Bloom
The paper shows that mitochondrial response to nutrients is disrupted early in the cortex of APPSAA mice before symptoms appear, suggesting it as a presymptomatic event in Alzheimer's disease.
Alzheimer s & Dementia · Aug 22, 2024Peer-reviewedNeuroscience