Ammasi Periasamy

The paper shows that mitochondrial NADK2-dependent NADPH synthesis mediates Tau oligomer uptake in neurons via LRP1, creating a cycle that exacerbates TauO toxicity.

The paper shows that mitochondrial response to nutrients is disrupted early in the cortex of APPSAA mice before symptoms appear, suggesting it as a presymptomatic event in Alzheimer's disease.

The paper identifies SOD1 as a mediator of lysosome-to-mitochondria communication and shows its dysregulation by amyloid-β oligomers in Alzheimer's disease.