Disruption of the CSF-1-CSF-1R axis alters cerebellar microglia and is associated with motor and social interaction defects
Veronika Kana, Fiona A. Desland, María Casanova-Acebes, Pinar Ayata, Ana Badimon, Elisa M. Nabel, Kazuhiko Yamamuro, Marjolein A. M. Sneeboer, I‐Li Tan, Meghan E. Flanigan, Samuel A. Rose, Christie Chang, Andrew M. Leader, Hortense Le Bourhis, Eric S. Sweet, , Miriam Mérad
This study shows that CSF-1 signaling is essential for cerebellar microglia identity and function, and its disruption causes motor and social behavior defects.
The Journal of Experimental Medicine · Jul 26, 2019Peer-reviewedNeuroscience