Author

Houxin He

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Chen FangiD· 1 shared Haoran WangiD· 1 shared Huanhuan WuiD· 1 shared Jiaxin HuiD· 1 shared Limeng Tian· 1 shared Wentao CuiiD· 1 shared Xiaoning QiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Chen FangORCID

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1 paper

Recent·Most cited

A closed-loop language-model agent for target-specific multi-objective hit-to-lead optimization

Wentao Cui, Limeng Tian, Xiaoning Qi, Haoran Wang, Huanhuan Wu, Houxin He, Chen Fang, Jiaxin Hu

This paper develops a language-model agent for hit-to-lead optimization that outperforms existing methods on four kinase targets in a computational benchmark.

bioRxiv · Sep 24, 2026 · PreprintBioinformatics