A Platform for Controlled Template-Independent Enzymatic Synthesis of RNA Oligonucleotides and Therapeutics
Daniel J. Wiegand, Jonathan Rittichier, Ella Meyer, Howon Lee, Nicholas J. Conway, Daniel Ahlstedt, Zeynep Yurtsever, Dominic Rainone, Erkin Kuru, George McDonald Church
The paper develops an aqueous-based enzymatic platform for template-independent RNA oligonucleotide synthesis, demonstrating compatibility with therapeutic modifications and offering a sustainable alternative to chemical methods.
Nature Biotechnology · Jul 12, 2024Peer-reviewedSynthetic Biology