Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in mice
Subashree Murugan, Sachin Anil Ghag, Viviane Souza de Campos, Hsuan-Yeh Pan, Marianne O. Price, Francis W. Price, Rajalekshmy Shyam
This study shows proteasomal dysfunction causes ER stress, endo-mesenchymal transition, oxidative stress, and apoptosis in mice, leading to FECD-like features.
bioRxiv · Apr 11, 2025 · PreprintCell Biology