Author

Rajalekshmy Shyam

Indiana University BloomingtonORCID 0000-0003-2154-4173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Sachin Anil GhagiD· 2 shared Subashree MuruganiD· 2 shared Viviane Souza de CamposiD· 2 shared Francis W. PriceiD· 1 shared Hsuan-Yeh Pan· 1 shared Marianne O. PriceiD· 1 shared Samuel HerbergiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Sachin Anil GhagORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 8, 2025

Decreased substrate stiffness leads to mitochondrial dysfunctions and Endothelial to Mesenchymal transition through Focal Adhesion Kinase activity in corneal endothelial cells

Sachin Anil Ghag, Viviane Souza de Campos, Subashree Murugan…·Rajalekshmy Shyam

This study investigates how reduced substrate stiffness affects corneal endothelial cell health, finding increased FAK activity and EndMT, but no improvement in disease progression with FAK inhibition.

DOI 10.1101/2025.11.08.687366

mouseexperimental assay

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Cell BiologybioRxivPreprintApr 11, 2025

Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in mice

Subashree Murugan, Sachin Anil Ghag, Viviane Souza de Campos…·Rajalekshmy Shyam

This study shows proteasomal dysfunction causes ER stress, endo-mesenchymal transition, oxidative stress, and apoptosis in mice, leading to FECD-like features.

1 citation

mouseproteomics

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