Oncolytic Adenovirus Armed with cGAS Activates STING Pathway and Enhances Antitumor Immunity in Lung Cancer with Superior Combined Efficacy of PD-L1 Therapy
Qingwen Wang, Hua-wei Xu, Yusen Shi, Yi-Peng Zhang, J. B. Jörger jun, Dan-Ning Yue, Weidong Zhao, Jia-Qiang Huang, Xiang-Lei Peng, Jie-Mei Yu, Jin-sheng He, Yan-Peng Zheng, Yuan-Hui Fu
This study develops oncolytic adenoviruses expressing cGAS to activate the STING pathway and enhance antitumor immunity in lung cancer, showing improved efficacy when combined with PD-L1 therapy.
Frontiers in Immunology · Jul 23, 2026Peer-reviewedImmunology