DNA sequence quantitatively encodes CTCF-binding affinity at genome scale
Zihang Yin, Yefan Wang, Guojun Hou, Yuqiao Chen, Huaijin Feng, Jin Zhu, Yufan Xie, Ruoxi Wang, Zhiyu Zhang, Tao Wu, Haiyan Huang, Sheila Q. Xie, Wuming Wang, Wenchao Gu, Qiang Wu, , Ya Guo
The paper experimentally measures CTCF-binding affinity across 276,765 human DNA sequences and develops a deep learning model to predict and interpret binding strength based on sequence features.
bioRxiv · Jan 5, 2026 · PreprintGenomics