The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis
Xialian Wu, Hong Hu, Xingqi Dong, Jing Zhang, Jian Wang, Charles Schwieters, Jing Liu, Guo xiang Wu, Bing Li, Jing yu Lin, Huayi Wang, Junxia Lu
This study structures and functionally characterizes the mouse RIPK3 amyloid complex in necroptosis, revealing a unique N-shaped core and a structural transformation from hetero- to homo-oligomer.
bioRxiv · Jul 10, 2020Biochemistry