Author

Huayu Li

Shenzhen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:protein structure prediction· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Huan DuiD· 2 shared Li LiuiD· 2 shared Yang LiuiD· 2 shared Anthony GitteriD· 1 shared Ao LiiD· 1 shared Aoxiang Xu· 1 shared Brett J. BakeriD· 1 shared Chenchen HaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Huan DuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Medicinal Chemistry-Centered Evaluation of AlphaFold 3 and Boltz-2 Across Diverse Binding Modalities

Ke Chen, Zuohuang Qi, O L Ramos, Huayu Li, Mengjiao Ma, Malla Reddy Gannarapu, Fangchao Bi, Ao Li, Hongmin Li, Rui Xiong

This study evaluates AlphaFold 3 and Boltz-2 for predicting biomolecular structures across diverse binding types, finding they accurately predict some complexes but struggle with others like allosteric and membrane-protein interactions.

bioRxiv · Aug 26, 2026 · PreprintBiochemistry

Microcompartments in archaeal ancestors of eukaryotes: a bioenergetic engine that could have fuelled eukaryogenesis

Huan Du, Aoxiang Xu, Xiaoyuan Feng, Wen-Cong Huang, Huayu Li, Li Liu, Yuling Li, Siyu Zhang, Ning Song, Kathryn E. Appler, Brett J. Baker, Eugene V. Koonin, Meng Li, Yang Liu

The paper identifies archaeal microcompartments in Hodarchaeales, showing they enhance energy production and may have contributed to eukaryogenesis.

bioRxiv · Nov 8, 2025 · PreprintMicrobiology

Decoding the Molecular Language of Proteins with Evolla

Xibin Zhou, Chenchen Han, Yingqi Zhang, Huan Du, Jiayuan Tian, Jin Su, Renju Liu, Kai Zhuang, Shiyu Jiang, Anthony Gitter, Li Liu, Huayu Li, Meiqi Wu, Shiyang You, Zichen Yuan, , Fajie Yuan

Evolla, a protein-language model, improves functional inference and discovers novel proteins through natural language queries and benchmarking.

bioRxiv · Jan 5, 2025 · PreprintBioinformatics