BiochemistrybioRxivPreprint
A Medicinal Chemistry-Centered Evaluation of AlphaFold 3 and Boltz-2 Across Diverse Binding Modalities
Ke Chen, Zuohuang Qi, O L Ramos…·Rui Xiong
This study evaluates AlphaFold 3 and Boltz-2 for predicting biomolecular structures across diverse binding types, finding they accurately predict some complexes but struggle with others like allosteric and membrane-protein interactions.
DOI 10.64898/2026.08.24.746785