Hongmin Li

A Medicinal Chemistry-Centered Evaluation of AlphaFold 3 and Boltz-2 Across Diverse Binding Modalities

This study evaluates AlphaFold 3 and Boltz-2 for predicting biomolecular structures across diverse binding types, finding they accurately predict some complexes but struggle with others like allosteric and membrane-protein interactions.

TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy

This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.

Identification and characterization of UBA5 inhibitors

This study identifies five novel UBA5 inhibitors through HTS, showing selectivity and efficacy in inhibiting UFMylation, with potential for therapeutic applications in neurodegenerative diseases and cancer.

Prominent elevation of extracellular matrix molecules in intracerebral hemorrhage

This study identifies elevated extracellular matrix molecules, particularly neurocan, in murine and human intracerebral hemorrhage, which inhibit oligodendrocyte precursor cell function and may impair repair.

Recurrent de novo single point mutation on the gene encoding Na+ /K+ pump results in epilepsy

The paper identifies a de novo mutation in ATP1A2 causing epilepsy in a family and creates a mouse model to study its effects on seizures and cognitive function.