The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA mediated inherited silencing
Yue‐He Ding, Humberto J. Ochoa, Takao Ishidate, Masaki Shirayama, Craig C. Mello
This study shows HRDE-1 promotes heterochromatin silencing and small-RNA amplification in C. elegans, establishing a self-enforcing mechanism for transgenerational silencing.
Cell Reports · Apr 20, 2023Peer-reviewedGenetics