Yue‐He Ding

This study shows HRDE-1 promotes heterochromatin silencing and small-RNA amplification in C. elegans, establishing a self-enforcing mechanism for transgenerational silencing.

This study shows that SUMOylation of HDA-1 in C. elegans is required for Argonaute-directed transcriptional silencing by facilitating interactions with the NuRD complex and nuclear Argonaute HRDE-1/WAGO-9.

The paper shows PIE-1 promotes SUMOylation and activation of HDAC1 in C. elegans oogenesis, enhancing Argonaute-mediated surveillance.

Open-pFind improves peptide identification in shotgun proteomics by handling complex modifications and increasing identification rates and speed.

C-BERST uses dCas9-APEX2 to map proteomes near genomic loci, identifying telomere and centromere-associated proteins.

The paper identifies piRNA binding sites in C. elegans germline mRNAs and shows piRNA targeting follows microRNA-like rules, with binding energy more important than piRNA abundance.