Granulin+ macrophages promote lineage plasticity in prostate cancer through paracrine signaling loops
Zhipeng Zhu, Mi Zhang, Ying Song, Wei Jiang, Fang Cao, Yicong Yao, Xiaotong Yu, Hongyu Zhao, Husile Baiyin, De Chang, Denglong Wu, Xiaolu Zhao, Gang Wu, Kailong Li, Fengbiao Mao
This study identifies granulin+ macrophages as drivers of lineage plasticity in prostate cancer through paracrine signaling loops, promoting drug resistance.
bioRxiv · Jul 9, 2025 · PreprintCancer Biology