Author

De Chang

Chinese PLA General HospitalORCID 0000-0001-9767-6901Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Denglong WuiD· 1 shared Fang CaoiD· 1 shared Fengbiao MaoiD· 1 shared Gang WuiD· 1 shared Hongyu ZhaoiD· 1 shared Husile Baiyin· 1 shared Kailong LiiD· 1 shared Mi ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Denglong WuORCID

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1 paper

Recent·Most cited

Granulin+ macrophages promote lineage plasticity in prostate cancer through paracrine signaling loops

Zhipeng Zhu, Mi Zhang, Ying Song, Wei Jiang, Fang Cao, Yicong Yao, Xiaotong Yu, Hongyu Zhao, Husile Baiyin, De Chang, Denglong Wu, Xiaolu Zhao, Gang Wu, Kailong Li, Fengbiao Mao

This study identifies granulin+ macrophages as drivers of lineage plasticity in prostate cancer through paracrine signaling loops, promoting drug resistance.

bioRxiv · Jul 9, 2025 · PreprintCancer Biology