Idebenone Enhances the Early Microglial Response to Traumatic Brain Injury and Mitigates Acute Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways
Hyehyun Hwang, Chinmoy Sarkar, Boris Piskoun, Naibo Zhang, Apurva Borcar, Courtney Robertson, Marta M. Lipinski, Nagendra Yadava, Molly J. Goodfellow, Brian M. Polster
This study shows idebenone enhances microglial activation after TBI but reduces gene expression changes in dopamine and Ephrin-A signaling pathways.
bioRxiv · May 6, 2025 · PreprintNeuroscience