Chinmoy Sarkar

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.

This study shows idebenone enhances microglial activation after TBI but reduces gene expression changes in dopamine and Ephrin-A signaling pathways.