Marta M. Lipinski

Rubicon modulates neuroimmune responses following traumatic brain injury

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

Protective Role of Galectin-3 in Prion Disease Through Regulation of Microglial PrPSc Uptake

This study shows that Galectin-3 promotes microglial uptake of PrPSc, slowing prion disease progression by enhancing phagocytic sequestration of prions.

Lysosomal multi-omics reveals altered sphingolipid catabolism as driver of lysosomal dysfunction in the aging brain.

The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.

Idebenone Enhances the Early Microglial Response to Traumatic Brain Injury and Mitigates Acute Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways

This study shows idebenone enhances microglial activation after TBI but reduces gene expression changes in dopamine and Ephrin-A signaling pathways.

Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila

This study investigates genetic modifiers of traumatic brain injury responses in Drosophila using a high-throughput trauma model, identifying factors that influence acute and long-term outcomes.

N-acetyl-L-leucine treatment attenuates neuronal cell death and suppresses neuroinflammation after traumatic brain injury in mice