Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
Junhong Kim, Hyeonjin Na, Siyoung Choi, Eun Ju Oh, Hyun‐Sook Lee, Sung Ho Ryu, Na-Oh Yunn, Yunje Cho
The paper determines the structure of the insulin receptor complexed with a dimeric aptamer agonist, revealing how it induces full activation through specific conformational changes and intermolecular phosphorylation.
Experimental & Molecular Medicine · Jul 2, 2025Peer-reviewedBiochemistry