Siyoung Choi

This paper identifies Aurora B-mediated phosphorylation and acetylation of BubR1 as critical for SAC signaling, linking kinetochore attachment to checkpoint activity and offering therapeutic targets for chromosome instability cancers.

The paper determines the structure of the insulin receptor complexed with a dimeric aptamer agonist, revealing how it induces full activation through specific conformational changes and intermolecular phosphorylation.

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.