BiochemistryExperimental & Molecular MedicinePeer-reviewed
Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
Junhong Kim, Hyeonjin Na, Siyoung Choi…·Yunje Cho
The paper determines the structure of the insulin receptor complexed with a dimeric aptamer agonist, revealing how it induces full activation through specific conformational changes and intermolecular phosphorylation.
4 citations