Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer
Brett Schroeder, Jae Choi, Alejandro A. Schäffer, Michael Nirula, Yingying Cao, Yang Zhang, Anna-Lena Meinhardt, Hyeokjun Kwon, Hyerim Park, Sangin Lee, Hyo Jin Shin, Hee Geon Park, Hobin Yang, Sungyoul Hong, Parth Desai, , Anish Thomas
The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.
bioRxiv · Jul 30, 2026 · PreprintCancer Biology