Yingying Cao

The paper identifies spatially organized tertiary lymphoid structures in small cell lung cancer and links their presence to improved patient survival.

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

scBubbletree provides a scalable visualization method for scRNA-seq data by clustering cells into bubbles on dendrograms, enabling quantitative assessment and biological interpretation.

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

The paper investigates epigenetic mechanisms driving cell state transitions in chondrocytes by analyzing histone modifications and gene expression during differentiation.