Author

Yang Zhang

National Institutes of HealthORCID 0000-0002-1046-4752Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yang Zhang9 papers · St. Jude Children's Research Hospital

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

Anish ThomasiD· 4 shared Ajit Kumar SharmaiD· 3 shared Michael NirulaiD· 3 shared Parth Anil DesaiiD· 3 shared Yingying CaoiD· 3 shared Yue HuangiD· 3 shared Abhinav JoshiiD· 2 shared Amira Z KaziiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Anish ThomasORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Amira Z Kazi, Yingying Cao, Chirayu Mohindroo, Abhinav Joshi, Yang Zhang, Yue Huang, Chiori Tabe, Brett Schroeder, Þorkell Andrésson, Ajit Kumar Sharma, Anish Thomas

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

Brett Schroeder, Jae Choi, Alejandro A. Schäffer, Michael Nirula, Yingying Cao, Yang Zhang, Anna-Lena Meinhardt, Hyeokjun Kwon, Hyerim Park, Sangin Lee, Hyo Jin Shin, Hee Geon Park, Hobin Yang, Sungyoul Hong, Parth Desai, , Anish Thomas

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

bioRxiv · Jul 30, 2026 · PreprintCancer Biology

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao, Abhinav Joshi, Sophie Z. Zhuang, Amira Z Kazi, Michael Nirula, Sarthak Sahoo, Yang Zhang, Rajeswary Kumar, Seemadri Subhadarshini, Kanak Parmar, Melissa R. Mikolaj, Roshan L Shreshta, Tiyam Assadpour, , Anish Thomas

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

Christopher William Schultz, Sourav Taru Saha, Anjali Dhall, Yang Zhang, Parth Anil Desai, Lőrinc Sándor Pongor, David A. Scheiblin, Valentin Magidson, Yilun Sun, Christophe E. Redon, Suresh Kumar, Manan Krishnamurthy, Henrique Bregolin Dias, Vasilisa Aksenova, Elizabeth G Giordano, , Anish Thomas

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

bioRxiv · Apr 29, 2025 · PreprintCancer Biology