Myeloperoxidase promotes fibrosis by inhibiting cathepsin K to bias the lung toward ECM accumulation
Patrick A. Link, Jack H. Wellmerling, Jeffrey A. Meridew, Hyogo Naoi, Y. S. Prakash, Mauricio M. Rojas, Eva M. Carmona, Daniel J. Tschumperlin
This study identifies MPO as a post-translational inhibitor of CatK, linking acute inflammation to sustained fibrosis through impaired collagen degradation.
bioRxiv · Apr 7, 2026 · PreprintPathology