Mauricio M. Rojas

The paper integrates single-cell RNA sequencing and spatial transcriptomics to identify CTHRC1+ fibroblasts as key fibrogenic cells in IPF, showing how culture affects their transcriptional profile.

This study identifies MPO as a post-translational inhibitor of CatK, linking acute inflammation to sustained fibrosis through impaired collagen degradation.

This study uses MALDI-MSI to analyze lipids and proteins in human lung fibroblasts, revealing senescence-related changes at the single-cell level.

The paper identifies LEF1 isoforms as key regulators of cellular senescence and aging through transcriptomic analysis and validation in human and mouse models.

The paper identifies TWIST1 as a critical regulator of myofibroblast activity in IPF using single-nucleus ATAC-seq and scRNA-seq integration.

The paper identifies early fibroblast transitions to a profibrotic state in IPF using scRNA-seq and validates MOXD1 as an early marker.

The paper uses spatial transcriptomics and the MAPLE algorithm to analyze fibrotic lung tissue, identifying spatial biomarkers and fibrotic programs in IPF.

This study shows TSC2 deficiency in pulmonary vascular smooth muscle cells leads to ECM remodeling, hyper-proliferation, and pulmonary hypertension, which can be reversed by restoring TSC2 function.