Author

Jack H. Wellmerling

Mayo ClinicORCID 0000-0002-5462-7744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Daniel J. TschumperliniD· 2 shared Mauricio M. RojasiD· 2 shared Ahmed H. GhobashiiD· 1 shared Ana Lucia MoraiD· 1 shared Brenda F. ReaderiD· 1 shared Brigitte N. GompertsiD· 1 shared Chandani SeniD· 1 shared Eva M. CarmonaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Daniel J. TschumperlinORCID

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2 papers

Recent·Most cited

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis

Natalia Vanegas-Avendaño, H. Chen, Jack H. Wellmerling, Jhonny Rodriguez-Lopez, Ahmed H. Ghobashi, Victor Peters, Chandani Sen, Brenda F. Reader, Konstantin Shilo, Brigitte N. Gomperts, Qin Ma, Ana Lucia Mora, Daniel J. Tschumperlin, Mauricio M. Rojas

The paper integrates single-cell RNA sequencing and spatial transcriptomics to identify CTHRC1+ fibroblasts as key fibrogenic cells in IPF, showing how culture affects their transcriptional profile.

bioRxiv · Apr 10, 2026 · PreprintMolecular Biology

Myeloperoxidase promotes fibrosis by inhibiting cathepsin K to bias the lung toward ECM accumulation

Patrick A. Link, Jack H. Wellmerling, Jeffrey A. Meridew, Hyogo Naoi, Y. S. Prakash, Mauricio M. Rojas, Eva M. Carmona, Daniel J. Tschumperlin

This study identifies MPO as a post-translational inhibitor of CatK, linking acute inflammation to sustained fibrosis through impaired collagen degradation.

bioRxiv · Apr 7, 2026 · PreprintPathology