Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease
Gilad Sahar Green, Masashi Fujita, Hyun-Sik Yang, Mariko F. Taga, Cristin Aubin, Anael Cain, Charles C. White, Anna K. Schmidtner, Lu Zeng, Yangling Wang, Aviv Regev, Vilas Menon, David Alan Bennett, Naomi Habib, Philip L. De Jager
The paper identifies two distinct aging trajectories in the human brain linked to Alzheimer's disease or alternative aging, using single-nucleus RNA-seq data and causal modeling.
Alzheimer s & Dementia · Dec 1, 2023Peer-reviewedNeuroscience