Charles C. White

Evaluation of potential serum analytes for individuals at-risk of multiple sclerosis

This study evaluates six potential serum biomarkers for multiple sclerosis in at-risk individuals and finds most are not robust predictors, though SPP1 shows a significant inverse correlation with genetic risk.

Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease

This study investigates the genetic overlap between inflammatory bowel disease and Alzheimer's disease, finding distinct myeloid cell-specific risk factors and some protective associations.

A Radiomic Approach to Clinical MRI Refines the Thalamus-Cognition Link in Multiple Sclerosis

This study uses radiomic features from thalamic nuclei to identify associations with cognitive performance in multiple sclerosis patients, finding radiomic features outperform volumetric measures.

HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures in vitro

The paper uses HDAC inhibitors to mimic human DAM in vitro and identifies shared marker genes.

Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease

The paper identifies two distinct aging trajectories in the human brain linked to Alzheimer's disease or alternative aging, using single-nucleus RNA-seq data and causal modeling.

Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

The paper maps cellular changes in the aging human brain and identifies altered multicellular communities in Alzheimer's disease using single nucleus RNA-seq and bulk RNA-seq data.

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Neuroticism alters the transcriptome of the frontal cortex to contribute to the cognitive decline and onset of Alzheimer's disease

This study shows neuroticism significantly affects the brain transcriptome and may mediate cognitive decline and Alzheimer's disease through TAU pathology-related gene expression.

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

The paper reports a detailed genetic and genomic map of multiple sclerosis, identifying susceptibility genes in peripheral immune cells and brain-resident microglia.

A molecular network of the aging brain implicates INPPL1 and PLXNB1 in Alzheimer’s disease

Molecular network analysis of RNA sequencing data from the aging human cortex identifies new Alzheimer's and cognitive decline genes.

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

This study performs a large GWAS of Alzheimer's disease, identifies four new risk loci, and highlights pathways involving immunity, lipid metabolism, and APP/Aβ processing.

A cortical immune network map identifies a subset of human microglia involved in Tau pathology

The paper identifies gene modules in human frontal cortex microglia associated with beta-amyloid and tau pathology in Alzheimer's disease.

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

Brain xQTL Map: Integrating The Genetic Architecture Of The Human Brain Transcriptome And Epigenome

The paper identifies xQTLs in the human brain integrating RNA, DNA methylation, and histone acetylation data from 411 individuals, revealing 18 new CNS disease susceptibility loci.