Naomi Habib

The paper identifies subtle cognitive, behavioral, and physiological features in preclinical Alzheimer's disease using a risk factor-controlled cohort and an AI classifier.

The paper analyzes microglial communication in Alzheimer's disease using single-nucleus RNA sequencing to identify altered signaling pathways and cell interactions associated with disease pathology.

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

This study establishes an ex vivo brain slice culture platform to study glial cell responses and multicellular communication in adult human brain tissue.

DeepDynamics uses bulk RNA-seq and sc/snRNA-seq to infer cell-subtype and clinicopathological dynamics in Alzheimer's disease, identifying risk mediators in APOE4 carriers.

The paper identifies cell type-specific gene modules associated with Alzheimer's Disease traits using snRNASeq data from human brain tissues.

The paper identifies early transcriptional changes in neuronal subtypes in Alzheimer's disease using single-nucleus RNA data, revealing distinct programs linked to vulnerability and resilience.

The paper uses snRNA-seq to analyze human subcutaneous and visceral adipose tissue, identifying classical and specialized adipocyte subtypes and depot-specific patterns.

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

The paper identifies two distinct aging trajectories in the human brain linked to Alzheimer's disease or alternative aging, using single-nucleus RNA-seq data and causal modeling.

The paper maps cellular changes in the aging human brain and identifies altered multicellular communities in Alzheimer's disease using single nucleus RNA-seq and bulk RNA-seq data.

This study shows that obesity accelerates cognitive decline in Alzheimer's mice via sialic acid-driven immune changes.

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

This paper introduces an MRI technique to assess iron homeostasis in living human brains, showing it varies with age and disease states.

This study constructs a single-cell and spatial atlas of the choroid plexus in developing and adult mice, revealing cell types, regional gene expression, and cell-cell interactions.

The paper introduces a method to multiplex single-nucleus RNA-seq using barcoded antibodies, reducing costs and enabling large-scale studies.

DroNc-Seq enables high-throughput single nucleus RNA-seq analysis of archived brain tissues, demonstrating efficient and unbiased cell type classification in mouse and human samples.

Div-Seq tracks transcriptional dynamics of rare adult newborn neurons using single nucleus RNA-Seq and EdU labeling.