Computational docking reveals evolutionary conservation of a specific interaction between 15d-Prostaglandin-J2 and eIF4A.
So Jeong Yun, Hyunjoon Kim, Seung Gee Lee, Seung-Hyun Jung, Joon Hyun Kim, Jeong Eun Ryu, N. Jiten Singh, Jouhyun Jeon, Jin‐Kwan Han, Cheol‐Hee Kim, Sanguk Kim, Kwang S. Kim, Sung Key Jang, Woo Jae Kim
The paper uses computational docking to show that 15d-PGJ2 binds to eIF4A, blocking eIF4G interaction and forming stress granules, with conserved binding sites across species.
bioRxiv · Dec 29, 2017 · PreprintMolecular Biology