Anti-vitronectin single-chain variable fragment targeting the hemopexin-like domain decreases age-related macular degeneration indicators in ex vivo models of the retinal pigment epithelium
Jun W. Kim, SUSANNE R. MEYER, Ben Lopez, Mohamed A. Faynus, Lincoln V. Johnson, Houman D. Hemmati, Dennis Clegg, Hyunsuk Min
The paper develops an anti-vitronectin antibody that reduces drusen accumulation and complement pathway activation in an in vitro model of age-related macular degeneration.
bioRxiv · Aug 18, 2025 · PreprintCell Biology