Jun W. Kim

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

The paper develops an anti-vitronectin antibody that reduces drusen accumulation and complement pathway activation in an in vitro model of age-related macular degeneration.

This study combines machine learning and high-throughput screening to design improved nuclease enzymes, finding a more effective variant than standard directed evolution methods.