Author

Mohamed A. Faynus

University of California, Santa BarbaraORCID 0000-0002-5627-2465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Dennis CleggiD· 2 shared Alex ChialastriiD· 1 shared Alex J. Goldstein· 1 shared Alison Schroer Vander RoestiD· 1 shared Bárbara Mejía‐CupajitaiD· 1 shared Ben Lopez· 1 shared Beth L. PruittiD· 1 shared Brock RobertsiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Dennis CleggORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 2, 2025

Progranulin loss induces mitochondrial dysfunction and ferroptosis in human cerebral organoids

Carolina M. Camargo, Maria Camila Almeida, Bárbara Mejía‐Cupajita…·K S Kosik

This study shows that PGRN loss in human cerebral organoids causes mitochondrial dysfunction and ferroptosis through oxidative stress and iron accumulation.

1 citation

humanscRNA-seq

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Cell BiologybioRxivPreprintAug 18, 2025

Anti-vitronectin single-chain variable fragment targeting the hemopexin-like domain decreases age-related macular degeneration indicators in ex vivo models of the retinal pigment epithelium

Jun W. Kim, SUSANNE R. MEYER, Ben Lopez…·Hyunsuk Min

The paper develops an anti-vitronectin antibody that reduces drusen accumulation and complement pathway activation in an in vitro model of age-related macular degeneration.

DOI 10.1101/2025.08.18.670968

humanproteomics

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Cell BiologybioRxivPreprintJun 3, 2024

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

Orlando Chirikian, Mohamed A. Faynus, Markus W. Merk…·Beth L. Pruitt

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky