Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike Protein
Theocharis Tsoleridis, I Singh, David Onion, Joseph G. Chappell, A Kelly, Jessica Nightingale, Ana Maria Valdes, Ben J. Ollivere, Kenneth B. Hoehn, Richard A. Urbanowicz, Jonathan K. Ball
This study shows that pre-Omicron immunity generates IgG+ but not IgA+ memory B cells reactive to Omicron spike protein, indicating broad antigenic recognition but weakened mucosal antibody defense.
bioRxiv · Sep 26, 2025 · PreprintImmunology