Author

Joseph G. Chappell

University of NottinghamORCID 0000-0002-8205-4242Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jonathan K. BalliD· 2 shared Richard A. UrbanowicziD· 2 shared Theocharis TsoleridisiD· 2 shared A Kelly· 1 shared Adam KirbyiD· 1 shared Alexander W. TarriD· 1 shared Ana Maria ValdesiD· 1 shared Andrew I. FlyakiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Jonathan K. BallORCID

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2 papers

Recent·Most cited

Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike Protein

Theocharis Tsoleridis, I Singh, David Onion, Joseph G. Chappell, A Kelly, Jessica Nightingale, Ana Maria Valdes, Ben J. Ollivere, Kenneth B. Hoehn, Richard A. Urbanowicz, Jonathan K. Ball

This study shows that pre-Omicron immunity generates IgG+ but not IgA+ memory B cells reactive to Omicron spike protein, indicating broad antigenic recognition but weakened mucosal antibody defense.

bioRxiv · Sep 26, 2025 · PreprintImmunology

An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses.

Theocharis Tsoleridis, Chengcheng Fan, Emily J. Park, Joshua D. Duncan, Parul Sharma, Sophie Wartnaby, Joseph G. Chappell, Anja Kipar, Eleanor G. Bentley, Adam Kirby, Ximeng Han, Christopher M. Coleman, Igor Andrade Santos, Dalan Bailey, Andrew I. Flyak, , Jonathan K. Ball

This study identifies two bovine-derived monoclonal antibodies with ultra-long CDRH3 domains that broadly neutralize SARS-CoV-2 and sarbecoviruses.

bioRxiv · Jan 3, 2025 · PreprintImmunology