Pharmacology & ToxicologyACS Chemical BiologyPeer-reviewed
Degradation of the TEAD-YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules that Bind to the TEAD Allosteric Lipid Pocket
I‐Ju Yeh, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Samy O. Meroueh
This study designs and tests heterobifunctional small molecules to degrade the TEAD-YAP/TAZ complex in cancer cells, showing significant proteasomal degradation with methyl ester analogs.
DOI 10.1021/acschembio.6c00170