Author

Samy O. Meroueh

University of Illinois Urbana-ChampaignORCID 0000-0002-3948-7499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Approach:comparative / phylogenetic analysis· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Khuchtumur Bum-ErdeneiD· 3 shared Mona K. GhozayeliD· 3 shared Giovanni Gonzalez-Gutierrez· 1 shared Giovanni González-GutiérreziD· 1 shared I‐Ju Yeh· 1 shared Mark J. ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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3 shared papersPharmacology & Toxicology

Khuchtumur Bum-ErdeneORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fragment Covalent Bond Formation at SOS1 Tyr-884 Inhibits KRAS Nucleotide Exchange

Khuchtumur Bum-Erdene, Giovanni Gonzalez-Gutierrez, Mona K Ghozayel, Samy Meroueh

This paper identifies a covalent inhibitor of SOS1-KRAS binding by screening fragments that form bonds at Tyr-884, showing time- and concentration-dependent inhibition of KRAS nucleotide exchange.

bioRxiv · Nov 4, 2026 · PreprintPharmacology & Toxicology

Degradation of the TEAD-YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules that Bind to the TEAD Allosteric Lipid Pocket

I‐Ju Yeh, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Samy O. Meroueh

This study designs and tests heterobifunctional small molecules to degrade the TEAD-YAP/TAZ complex in cancer cells, showing significant proteasomal degradation with methyl ester analogs.

ACS Chemical Biology · Apr 8, 2026Peer-reviewedPharmacology & Toxicology

A Fragment Screen Identifies Acrylamide Covalent Inhibitors of the TEAD/YAP Protein-Protein Interaction

Khuchtumur Bum‐Erdene, Mona K. Ghozayel, Mark J. Zhang, Giovanni González-Gutiérrez, Samy O. Meroueh

The paper identifies acrylamide fragments that covalently inhibit TEAD4-YAP interaction by reacting with a conserved cysteine in the TEAD palmitate pocket.

bioRxiv · Mar 20, 2026 · PreprintBiochemistry