Author

I. A. Mueller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:clustering· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:benchmark study· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. C. Hendershott· 3 shared S. M. Rafelski· 3 shared D. J. Thirstrup· 2 shared J. Arakaki· 2 shared R. N. Gunawardane· 2 shared R. Yang· 2 shared W. Wiegraebe· 2 shared A. Borensztejn· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCell Biology

M. C. Hendershott

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4 papers

Recent·Most cited

Mapping Protein Numbers in Living Cells

D. J. Thirstrup, J. Yao, J. Sherman, I. A. Mueller, W. Wiegraebe

The paper introduces a method to quantify protein numbers in live cells using fluorescence imaging and calibration curves, enabling 3D maps of protein density.

bioRxiv · Jul 2, 2021 · PreprintCell Biology

Automated hiPSC culture and sample preparation for 3D live cell microscopy

M. E. Coston, B. W. Gregor, J. Arakaki, A. Borensztejn, T. P. Do, M. A. Fuqua, A. Haupt, M. C. Hendershott, W. Leung, I. A. Mueller, A. M. Nelson, S. M. Rafelski, M. J. Swain-Bowden, W. J. Tang, D. J. Thirstrup, , N. Gaudreault

The paper describes an automated system for hiPSC culture and sample preparation to enable standardized 3D live cell imaging and analysis.

bioRxiv · Dec 18, 2020 · PreprintCell Biology

The Allen Cell and Structure Segmenter: a new open source toolkit for segmenting 3D intracellular structures in fluorescence microscopy images

J. Chen, L. Ding, M. P. Viana, H. Lee, M. F. Sluezwski, B. Morris, M. C. Hendershott, R. Yang, I. A. Mueller, S. M. Rafelski

The paper introduces the Allen Cell and Structure Segmenter, an open-source toolkit for 3D segmentation of intracellular structures in fluorescence microscopy images, achieving high accuracy through classic and deep learning workflows.

bioRxiv · Dec 13, 2020 · PreprintCell Biology

Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells

B. Roberts, J. Arakaki, K. A. Gerbin, H. Malik, A. Nelson, M. C. Hendershott, C. Hookway, S. A. Ludmann, I. A. Mueller, R. Yang, S. M. Rafelski, R. N. Gunawardane

The paper describes a CRISPR/Cas9 method to tag transcriptionally silent genes in hiPSCs with mEGFP, enabling visualization of sarcomeric proteins in live cardiomyocytes.

bioRxiv · Jun 9, 2018Cell Biology