Author

K. A. Gerbin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Nelson· 3 shared C. Yan· 3 shared M. C. Hendershott· 3 shared R. N. Gunawardane· 3 shared S. Q. Dinh· 3 shared T. Grancharova· 3 shared A. B. Rosenberg· 2 shared C. Hookway· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

A. Nelson

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Author profile →

5 papers

Recent·Most cited

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

T. Grancharova, K. A. Gerbin, A. B. Rosenberg, C. M. Roco, J. Arakaki, C. DeLizzo, S. Q. Dinh, R. Donovan-Maiye, M. Hirano, A. Nelson, J. Tang, J. A. Theriot, C. Yan, V. Menon, S. P. Palecek, , R. N. Gunawardane

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

bioRxiv · Apr 22, 2021Cell Biology

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

M. P. Viana, J. Chen, T. A. Knijnenburg, R. Vasan, C. Yan, J. E. Arakaki, M. Bailey, B. Berry, A. Borensztejn, J. M. Brown, S. Carlson, J. A. Cass, B. Chaudhuri, K. R. Cordes Metzler, M. E. Coston, , Leung

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

bioRxiv · Dec 8, 2020 · PreprintCell Biology

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

K. A. Gerbin, T. Grancharova, R. Donovan-Maiye, M. C. Hendershott, J. Brown, S. Q. Dinh, J. L. Gehring, M. Hirano, G. R. Johnson, A. Nath, A. Nelson, C. M. Roco, A. B. Rosenberg, M. F. Sluzewski, M. P. Viana, , R. N. Gunawardane

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

bioRxiv · May 26, 2020Cell Biology

Delta-1 functionalized hydrogel promotes hESC-cardiomyocyte graft proliferation and maintains heart function post-injury

K. A. Gerbin, K. A. Mitzelfelt, X. Guan, A. M. Martinson, C. E. Murry

This study shows that a Delta-1 functionalized hydrogel enhances hESC-CM proliferation and graft size, improving heart function after myocardial infarction with a lower cell dose.

bioRxiv · Sep 14, 2019Bioengineering

Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells

B. Roberts, J. Arakaki, K. A. Gerbin, H. Malik, A. Nelson, M. C. Hendershott, C. Hookway, S. A. Ludmann, I. A. Mueller, R. Yang, S. M. Rafelski, R. N. Gunawardane

The paper describes a CRISPR/Cas9 method to tag transcriptionally silent genes in hiPSCs with mEGFP, enabling visualization of sarcomeric proteins in live cardiomyocytes.

bioRxiv · Jun 9, 2018Cell Biology